Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers
US9688769B2 · kind B2 · utility
1Cited by
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18Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 22, 2014 |
| Grant date | Jun 27, 2017 |
| Priority date | — |
| Expiry date | Oct 22, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/102
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of Toll-like Receptor 4 (TLR4) ligands and other biomarkers. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder associated with elevated levels of TLR4 ligands and other biomarkers using agents that interfere with or otherwise antagonize TLR4 signaling, including neutralizing anti-TLR4 antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.