Microorganism producing o-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same
US9689009B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 2011 |
| Grant date | Jun 27, 2017 |
| Priority date | — |
| Expiry date | Oct 31, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/03003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.