Method for determining the size distribution of a mixture of particles using Taylor dispersion, and associated system
US9689786B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 26, 2013 |
| Grant date | Jun 27, 2017 |
| Priority date | — |
| Expiry date | May 13, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N15/0211
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for determining the size distribution of a mixture of molecule or particle species including the steps of: injecting a sample of the mixture to be analyzed inside a capillary in which an eluent is flowing; transporting the sample injected along the capillary from an injection section to a detection section thereof, in experimental conditions suitable to generate a Taylor dispersion phenomenon that is measurable at the level of the detection section; generating, by a suitable sensor included in the detection section, a signal characteristic of the Taylor dispersion of the transported sample; processing the detection signal in order to obtain an experimental Taylor signal S(t); and analyzing the experimental Taylor signal Ŝ(t), wherein the step of analyzing an experimental Taylor signal Ŝ(t) of a sample of the mixture consists of searching an amplitude distribution P(G(c)) that allows the experimental Taylor signal Ŝ(t)′ to be broken down into a sum of Gaussian functions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.