Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders

US9693957B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Wenbin Lin · Chicago, US
• Demin Liu · Round Lake, US
• Joseph Della Rocca · Blue Bell, US
• Stephanie Kramer · Johnson City, US
• Christopher Y. Poon · Carrboro, US

Key dates

• Filing date: Jul 9, 2012
• Grant date: Jul 4, 2017
• Expiry date: Apr 17, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.