Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy

US9694074B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES · FR
• The Regents of the University of California · US
• Ecole Nationale Supérieure de Chimie de Montpellier · FR

Inventors

• Frederique Cunin · Montpellier, FR
• Jean-Olivier Durand · Lattes, FR
• Michael J. Sailor · Village of La Jolla, US
• Marcel Garcia · Prades-le-Lez, FR
• Emilie Secret · Montpellier, FR
• Magali Gary-Bobo · Montpellier, FR
• Marie Maynadier · Apt, FR
• Alain Morere · Juvignac, FR

Key dates

• Filing date: Mar 26, 2013
• Grant date: Jul 4, 2017
• Expiry date: Mar 26, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.