Compounds for treating HIV and methods for using the compounds

US9695127B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Thomas E. Smithgall · Wexford, US
• Lori Emert-Sedlak · Oil City, US
• Billy W. Day · Pittsburgh, US
• Jielu Zhao · Blacksburg, US
• Prema C. Iyer · Pittsburgh, US

Key dates

• Filing date: Nov 6, 2013
• Grant date: Jul 4, 2017
• Expiry date: Dec 22, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity.