Solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and a coformer, compositions and methods of use thereof

US9695146B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• G. Patrick Stahly · Baton Rouge, US
• David Jonaitis · Lafayette, US
• Ho-Wah Hui · Berkeley Heights, US
• Kevin J. Klopfer · Flemington, US

Key dates

• Filing date: Mar 25, 2014
• Grant date: Jul 4, 2017
• Expiry date: Mar 25, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.