Oligooxopiperazines for p53 reactivation
US9695153B2 · kind B2 · utility
2Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Jan 21, 2014 |
| Grant date | Jul 4, 2017 |
| Priority date | — |
| Expiry date | Jan 21, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.