Heteroaryl inhibitors of sumo activating enzyme

US9695154B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Matthew O. Duffey · Chicago, US
• Dylan Bradley ENGLAND · Cambridge, US
• Zhigen Hu · Somerville, US
• Mitsuhiro Ito · Yokohama, JP
• Steven P. Langston · North Andover, US
• Charles McIntyre · Cambridge, US
• Hirotake Mizutani · Cambridge, US
• He Xu · Needham, US

Key dates

• Filing date: Jul 1, 2014
• Grant date: Jul 4, 2017
• Expiry date: Jul 1, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra′, Rc, Rf, X2, Rd, Rd′, Re, Re′, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.