Patent · US Active

Sialic acid (A-(2-6))-D-aminopyranose derivatives, synthesis methods and uses thereof

US9695208B2 · kind B2 · utility

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10Claims

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Assignee

Peking University · CN

Inventors

Xinshan Ye · Beijing, CN
Fan Yang · Brookline, US
Xiujing Zheng · Beijing, CN

Key dates

Filing date	Apr 8, 2011
Grant date	Jul 4, 2017
Priority date	—
Expiry date	Apr 20, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/6081
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.