Solid phase peptide synthesis processes and associated systems

US9695214B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Mark David Simon · Somerville, US
• Bradley L. Pentelute · Cambridge, US
• Andrea Adamo · Cambridge, US
• Patrick Louis Heider · Midland, US
• Klavs F. Jensen · Lincoln, US

Key dates

• Filing date: Feb 24, 2014
• Grant date: Jul 4, 2017
• Expiry date: Feb 24, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.