Microtubule-modifying compound

US9695239B2 · kind B2 · utility

Assignee

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE

Inventors

• Stefan Barth · Jena, DE
• Theopilus Thepen · Munich, DE
• Dmitrij Hristodorov · Wuppertal, DE
• Radoslav Mladenov · Zürich, CH

Key dates

• Filing date: Oct 24, 2013
• Grant date: Jul 4, 2017
• Expiry date: Oct 24, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A compound formed from at least one component A comprising a binding domain for extra-cellular surface structures of a diseased proliferating cell that internalized upon binding of component A of said compound, and at least one component B, characterized in that component B is a polypeptide which amino acid sequence comprises a microtubule-associated protein (MAP) or comprises at least a partial sequence of the MAP, the partial sequence having maintained the binding function of the MAP to a microtubule.