PSMA antibodies and uses thereof

US9695248B2 · kind B2 · utility

Assignee

• PSMA Development Company, LLC · US

Inventors

• Paul J. Maddon · Scarsdale, US
• Gerald P. Donovan · Kittery, US
• William Olson · Ossining, US
• Norbert Schuelke · East Walpole, US
• Jason Gardner · Wellesley, US
• Dangshe Ma · Millwood, US

Key dates

• Filing date: Sep 10, 2012
• Grant date: Jul 4, 2017
• Expiry date: Apr 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.