PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
US9695424B2 · kind B2 · utility
3Cited by
31References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2014 |
| Grant date | Jul 4, 2017 |
| Priority date | — |
| Expiry date | Sep 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.