Device and method for corneal delivery of riboflavin by iontophoresis for the treatment of keratoconus
US9700456B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 12, 2011 |
| Grant date | Jul 11, 2017 |
| Priority date | — |
| Expiry date | Mar 8, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F9/0008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm2; thereby obtaining the corneal cross-linking of the solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.