Strepsesquitriol, preparation method thereof, and application thereof

US9701603B2 · kind B2 · utility

Assignee

• SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Xianwen Yang · 红钢城街道, CN
• Kun Peng · Shanghai, CN
• Sumei Li · 流花街道, CN
• Gaiyun Zhang · 流花街道, CN
• Jie Li · Shanghai, CN
• Xiuping Lin · 流花街道, CN
• Yonghong Liu · Qingdao, CN

Key dates

• Filing date: Dec 30, 2013
• Grant date: Jul 11, 2017
• Expiry date: Dec 30, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention discloses a new strepsesquitriol A, a preparation method thereof and an application thereof. Strepsesquitriol A, a structure as shown in Formula (I), is a compound having a new skeleton and strongly inhibiting the formation of LPS-induced TNFα but showing no cytotoxic activity, so it can be used for the preparation of anti-inflammatory drug or act as a precursor of anti-inflammatory drugs, for the treatment of multiple inflammations. Therefore, the invention provides a new candidate compound for the development of anti-inflammatory drugs, and is of great significance for developing Chinese marine drug resources.