Hydrophobically modified antisense oligonucleotides comprising a ketal group
US9701962B2 · kind B2 · utility
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Key dates
| Filing date | Jun 5, 2014 |
| Grant date | Jul 11, 2017 |
| Priority date | — |
| Expiry date | Jun 5, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns an oligonucleotide modified by substitution at the 3′ or the 5′ end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.