Patent · US Active

System for trapping, interacting and modifying single protein molecules using a double-nanohole structure

US9702873B2 · kind B2 · utility

0Cited by

2References

30Claims

0Family size

Inventors

Reuven Gordon · Victoria, CA
Yuanjie Pang · Ann Arbor, US

Key dates

Filing date	Aug 12, 2013
Grant date	Jul 11, 2017
Priority date	—
Expiry date	Apr 1, 2035

Classification

Technology area (CPC G)Physics
CPC primaryG01N21/65
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Molecules or particle having a hydrodynamic radius as small as 3.5 nm can be trapped using a double-nanohole structure defined in a metal film or other metallic layer. Application of a suitable optical radiation flux to the double-nanohole structure can provide a folding and/or binding of protein molecules that can be identified based on changes in optical transmission. Varying nanohole transmissions can thus be associated with trapping, binding and unfolding of biological particles. The double-nanohole defines cusps, but such cusps can be defined in other ways as well.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.