Biochemically stabilized HIV-1 ENV trimer vaccine

US9707289B2 · kind B2 · utility

Assignees

• Children's Medical Center Corporation · US
• NATIONAL INSTITUTES OF HEALTH (NIH), THE UNITED STATES OF AMERICA DEPT. OF HEALTH AND HUMAN SERVICES (DHHS). · US

Inventors

• Stephen C. Harrison · Cambridge, US
• Bing Chen · Westwood, US
• Dan C. Barouch · Brookline, US
• Joseph P. Nkolola · Watertown, US
• Michael Scott Seaman · Dedham, US

Key dates

• Filing date: Apr 8, 2011
• Grant date: Jul 18, 2017
• Expiry date: Apr 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16171
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.