Pyrrolobenzodiazepines and targeted conjugates
US9707301B2 · kind B2 · utility
21Cited by
52References
10Claims
0Family size
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Key dates
| Filing date | Jun 15, 2016 |
| Grant date | Jul 18, 2017 |
| Priority date | — |
| Expiry date | Jun 15, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.