Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer

US9708276B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Zhou Wang · Aachen, DE
• Joel B. Nelson · Pittsburgh, US
• Minh Mindy Bao Nguyen · Shoreview, US
• John S. Lazo · Charlottesville, US
• Paul A. Johnston · Hawthorne, US
• Peter Wipf · Pittsburgh, US

Key dates

• Filing date: Oct 10, 2012
• Grant date: Jul 18, 2017
• Expiry date: Sep 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group;