Pyrrolopyrimidine nucleosides and analogs thereof

US9708359B2 · kind B2 · utility

Assignees

• CHIMERIX, INC. · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• John Henry Bougher, III · Durham, US
• Ramamurty V S Changalvala · Morrisville, US
• Aaron Leigh Downey · Durham, US
• John C. Drach · Ann Arbor, US
• Ernest Randall Lanier · Chapel Hill, US
• Andrew Louis McIver · Durham, US
• Bradley David Robertson · Durham, US
• Dean Wallace Selleseth · Durham, US
• Phiroze Behram Sethna · Durham, US
• Leroy B. Townsend · Ann Arbor, US
• Roy W. Ware · Raleigh, US

Key dates

• Filing date: Aug 8, 2016
• Grant date: Jul 18, 2017
• Expiry date: Aug 8, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/7064
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.