Stabilized alpha-galactosidase and uses thereof

US9708595B2 · kind B2 · utility

Assignee

• Protalix Ltd. · IL

Inventors

• Avidor Shulman · Rakefet, IL
• Ilya Ruderfer · Carmiel, IL
• Tehila Ben Moshe · Koranit, IL
• Talia Shekhter · Netanya, IL
• Yaniv Azulay · Kfar Refael, IL
• Yoseph Shaaltiel · Beit Hillel, IL
• Tali Kizhner · Sachnin, IL

Key dates

• Filing date: Nov 10, 2015
• Grant date: Jul 18, 2017
• Expiry date: Nov 10, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.