HiC: method of identifying interactions between genomic loci

US9708648B2 · kind B2 · utility

Assignees

• University of Massachusetts · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• Whitehead Institute For Biomedical Research · US

Inventors

• Job Dekker · Princeton, US
• Erez Lieberman Aiden · Cambridge, US
• Nynke Van Berkum · The Hague, NL
• Andreas Gnirke · Wellesley, US
• Eric S. Lander · Cambridge, US
• Chad Nusbaum · Newton, US
• Louise Williams · Reading, US
• Alexandre Melnikov · Bellingham, US
• Georgia Giannoukos · Cambridge, US

Key dates

• Filing date: Apr 25, 2016
• Grant date: Jul 18, 2017
• Expiry date: Apr 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/68
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.