Compositions and methods for identifying and diagnosing salt sensitivity of blood pressure

US9708664B2 · kind B2 · utility

Assignee

• University of Virginia Patent Foundation · US

Inventors

• Robin A. Felder · Charlottesville, US
• Robert M. Carey · Charlottesville, US
• John E. Jones, III · Seattle, US
• Pedro Jose · Mason Neck, US
• Scott Williams · Hanover, US

Key dates

• Filing date: Apr 22, 2013
• Grant date: Jul 18, 2017
• Expiry date: Sep 26, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/321
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ≧7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.