Spatial biomarker of disease and detection of spatial organization of cellular receptors
US9708665B2 · kind B2 · utility
1Cited by
5References
13Claims
0Family size
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Key dates
| Filing date | Jul 29, 2011 |
| Grant date | Jul 18, 2017 |
| Priority date | — |
| Expiry date | Jul 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.