Methods for making pharmaceutical solid dosage forms of spray-dried dispersions
US9713594B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Sep 5, 2013 |
| Grant date | Jul 25, 2017 |
| Priority date | — |
| Expiry date | Sep 5, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/4166
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An exemplary method comprises providing a spray-dried dispersion comprising particles, the particles comprising an active agent and a polymer, the dispersion particles having an average particle diameter of less than 50 μm. An ordered mixture is formed by high-shear mixing the dispersion with a powdered glidant, wherein the average particle diameter of the glidant is less than or equal to one fifth the average particle diameter of the dispersion after high-shear mixing. The dosage forms are formed by at least one of directly compressing the ordered mixture to form a tablet and encapsulating the ordered mixture to form a capsule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.