Suppression of bone loss by introducing FoxP3+ CD8 T-cells (TcREG)
US9713633B1 · kind B1 · utility
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Key dates
| Filing date | Feb 24, 2016 |
| Grant date | Jul 25, 2017 |
| Priority date | — |
| Expiry date | Feb 24, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/177
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist such as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.
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