Compositions and methods for improving glucose uptake

US9714259B2 · kind B2 · utility

Assignee

• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Nikhil V. Dhurandhar · Madison, US
• Bhaskar C. Das · West Nyack, US

Key dates

• Filing date: May 23, 2016
• Grant date: Jul 25, 2017
• Expiry date: May 23, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound includes the structure of general Formula II, pharmaceutically acceptable salts thereof, and/or solvates thereof:wherein R1, R2, R3, are independently selected from the group consisting of null, hydroxy, alkoxy, and halo, or R1 and R2 taken together form a cyclic boronate ester and R3 is null; wherein when four bonds to boron are present, boron bears a formal negative charge and the structure further comprises a countercation that is potassium or sodium, X1, X2, X3, and X4 are independently selected from the group consisting of O, CH, and N, with the proviso that no more than two of combined O and N are selected, and Z is selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, and halogen, any of which may be optionally substituted. Such compounds can increase glucose uptake by cells and preferably do not substantially increase adipogenesis.