Cyclosporine analogue molecules modified at amino acid 1 and 3
US9714271B2 · kind B2 · utility
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39Claims
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Key dates
| Filing date | Oct 30, 2015 |
| Grant date | Jul 25, 2017 |
| Priority date | — |
| Expiry date | Oct 30, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.