Growth differentiation factor 15 (GDF-15) polypeptides

US9714276B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Yumei Xiong · Palo Alto, US
• Yi Zhang · Nanjing, CN
• Jackie Z. Sheng · Thousand Oaks, US
• Agnes Eva Hamburger · Newbury Park, US
• Murielle Veniant-Ellison · Thousand Oaks, US
• Grant Shimamoto · Newbury Park, US
• Xiaoshan MIN · Burlingame, US
• Zhulun Wang · Palo Alto, US
• Jie Tang · Singapore, SG
• Gunasekaran Kannan · Daly City, US
• Kenneth W. Walker · Newbury Park, US
• Bryan D. LEMON · Mountain View, US

Key dates

• Filing date: Jan 28, 2013
• Grant date: Jul 25, 2017
• Expiry date: May 6, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.