Methods and compositions for unsilencing imprinted genes

US9714427B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Benjamin David Philpot · Durham, US
• Mark Zylka · Pasadena, US
• Bryan Roth · Moreland Hills, US
• John Arthur Allen · Galveston, US
• Hsien-Sung Huang

Key dates

• Filing date: Nov 9, 2011
• Grant date: Jul 25, 2017
• Expiry date: May 8, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/713
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.