Production of fatty alcohols from engineered microorganisms

US9714437B2 · kind B2 · utility

Assignee

• Codexis, Inc. · US

Inventors

• Kaman Chan · San Bruno, US
• Fernando Valle · Palo Alto, US
• Yoram Barak · Menlo Park, US
• Louis Clark · San Francisco, US
• Kristian Karlshoej · Naperville, US
• Jonathan Vroom · South San Francisco, US
• Jovana Nazor · Milpitas, US
• Claus M. Krebber · Mountain View, US
• Kenneth W. Mitchell · San Jose, US

Key dates

• Filing date: May 9, 2016
• Grant date: Jul 25, 2017
• Expiry date: May 9, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02E50/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”).