Method for regulating neurite growth
US9718857B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jun 19, 2012 |
| Grant date | Aug 1, 2017 |
| Priority date | — |
| Expiry date | May 24, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/705
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to a method of inhibiting neuronal cell death, including protecting neuronal cells from cell death and the effects of stress, such as high or low pH, comprising administering to the cells an effective amount of Teneurin C-terminal Associated Peptide (TCAP). The invention provides the use of TCAP to prevent and/or treat a number of brain conditions, such as hypoxia-ischemia and brain alkalosis or various brain or spinal cord injuries due to physical or physiological stresses. In one aspect the invention provides a use of TCAP to increase β-tubulin, β-actin levels in neuronal cells and/or to increase fasciculation among neuronal cells, in culture or in tissue. In another aspect, the invention provides a method of treating various pH induced neuronal conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.