OX40L fusion proteins and uses thereof
US9718870B2 · kind B2 · utility
1Cited by
9References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 27, 2015 |
| Grant date | Aug 1, 2017 |
| Priority date | — |
| Expiry date | May 27, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure provides OX40L huIgG4 fusion polypeptide subunits comprising a human IgG4 Fc domain, a trimerization domain, and the receptor binding domain of Ox40 ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.