Amphiphilic derivatives of thioether containing block copolypeptides

US9718921B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Timothy J. Deming · Summerland, US
• Jessica R. Kramer · Oakland, US
• April R. Rodriguez · Chino, US

Key dates

• Filing date: Feb 26, 2014
• Grant date: Aug 1, 2017
• Expiry date: Mar 21, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G69/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for preparation of novel amphiphilic derivatives of thioether containing block copolypeptides with narrow chain length distributions are described. These block copolymers can be chemically modified by oxidation and alkylation of the thioether containing residues. These materials generate self-assembled micelles, vesicles and hydrogels, or emulsions with oil phases. These assemblies can be used to encapsulate and delivery therapeutic molecules. The assemblies can be taken up by cells to release molecules from the assemblies.