Cells for producing recombinant iduronate-2-sulfatase
US9719074B2 · kind B2 · utility
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19References
26Claims
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Key dates
| Filing date | Aug 21, 2015 |
| Grant date | Aug 1, 2017 |
| Priority date | — |
| Expiry date | Aug 21, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/06013
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.