Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
US9719091B2 · kind B2 · utility
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Key dates
| Filing date | Jul 27, 2015 |
| Grant date | Aug 1, 2017 |
| Priority date | — |
| Expiry date | Jul 27, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/53
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2′-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2′-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.