Enhanced delivery of drug compositions to treat life threatening infections

US9724344B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• James E. Hitt · Midland, US
• True L. Rogers · Midland, US
• Brian D. Scherzer · Midland, US
• Ian B. Gillespie · Linden, US
• Paula C. Garcia · Midland, US
• Nicholas S. Beck · Midland, US
• Christopher J. Tucker · Midland, US
• Timothy J. Young · Bay City, US
• David A. Hayes · Midland, US
• Robert O. WILLIAMS, III · Austin, US
• Keith P. Johnston · Austin, US
• Jason Thomas McConville · Albuquerque, US
• Jay I. Peters · San Antonio, US
• Robert Talbert · San Antonio, US
• David Burgess · Worms, DE

Key dates

• Filing date: May 15, 2015
• Grant date: Aug 8, 2017
• Expiry date: Jul 8, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.