Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof

US9724352B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. · CN

Inventors

• Chunhao Yang · Shanghai, CN
• Linghua Meng · Shanghai, CN
• Yanhong Chen · Shanghai, CN
• Xiang Wang · 安丰镇, CN
• Cun Tan · Shanghai, CN
• Jiapeng Li · Beijing, CN
• Jian Ding · Shanghai, CN
• Yi Chen · Shanghai, CN

Key dates

• Filing date: Sep 19, 2016
• Grant date: Aug 8, 2017
• Expiry date: Sep 19, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D419/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a pyrrolo[2,1-f][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1-f][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1-f][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.