Patent · US Active

Stabilized trimeric HIV-1 GP41 fusion inhibitor polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif

US9724383B2 · kind B2 · utility

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1References

4Claims

0Family size

Assignee

New York Blood Center, Inc. · US

Inventors

Shibo Jiang · Floral Park, US
Zhi Qi · Great Neck, US
Xi Chen · Newton, US
Chungen Pan · Floral Park, US

Key dates

Filing date	Jul 10, 2015
Grant date	Aug 8, 2017
Priority date	—
Expiry date	Jul 23, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2740/16122
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.