Patent · US Active

Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders

US9724435B2 · kind B2 · utility

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5Claims

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Assignees

Inventors

Christopher R. McCurdy · Oxford, US
Christophe Mesangeau · Oxford, US
Frederick T. Chin · Ceres, US
Michelle L. James · Menlo Park, US
Bin Shen · Mountain View, US
Sanjiv S. Gambhir · Portola Valley, US
Sandip Biswal · Stanford, US
Deepak Behera · Noida, IN

Key dates

Filing date	Mar 4, 2014
Grant date	Aug 8, 2017
Priority date	—
Expiry date	Aug 19, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D491/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III′, or IV′:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.