Cytochrome P450 inhibitors and their method of use

US9725436B2 · kind B2 · utility

Assignee

• CORTENDO AB (PUBL) · SE

Inventors

• Benjamin E. Blass · Eagleville, US
• Magid A. Abou-Gharbia · Wilmington, US
• Wayne E. Childers · New Hope, US
• Pravin S. Iyer · Secunderabad, IN
• Joshodeep Boruwa · Hyderabad, IN

Key dates

• Filing date: Sep 15, 2014
• Grant date: Aug 8, 2017
• Expiry date: Sep 15, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke or incidentalomas.