Quinazoline derivative and preparation method therefor
US9725439B2 · kind B2 · utility
12Cited by
1References
16Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Sep 28, 2014 |
| Grant date | Aug 8, 2017 |
| Priority date | — |
| Expiry date | Sep 28, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.