Producing amines and diamines from a carboxylic acid or dicarboxylic acid or a monoester thereof

US9725746B2 · kind B2 · utility

Assignee

• EVONIK DEGUSSA GMBH · DE

Inventors

• Steffen Schaffer · Herten, DE
• Jasmin Corthals · Bochum, DE
• Mirja Wessel · Bochum, DE
• Hans-Georg Hennemann · Marl, DE
• Harald Haeger · Thedinghausen, DE
• Michael Volland · Karlsfeld, DE
• Martin Roos · Oestrich-Winkel, DE

Key dates

• Filing date: Dec 18, 2013
• Grant date: Aug 8, 2017
• Expiry date: Jan 2, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a whole-cell catalyst which expresses a recombinant α-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase which phosphopantetheinylates the fatty acid reductase, and which expresses, in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase, a transaminase, wherein the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and also to a process for converting a carboxylic acid or dicarboxylic acid or a monoester thereof to an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopantetheinylated fatty acid reductase or an α-dioxygenase and contacting the product with a transaminase.