Homo- and heterodimeric SMAC mimetic compounds as apoptosis inducers
US9730976B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Mar 16, 2016 |
| Grant date | Aug 15, 2017 |
| Priority date | — |
| Expiry date | Mar 16, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.