Patent · US Active

Peptides and uses thereof

US9732129B2 · kind B2 · utility

1Cited by

0References

18Claims

0Family size

Assignee

Fundacio Centre de Regulacio Genomica · ES

Inventors

Mark Isalan · Barcelona, ES
Mireia Garriga-Canut · Barcelona, ES

Key dates

Filing date	May 18, 2015
Grant date	Aug 15, 2017
Priority date	—
Expiry date	May 18, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be fused to effector domains for modulating gene expression. Zinc finger peptides of the invention are useful for targeting trinucleotide-repeat sequences in mutant genes and may have applications in gene therapy. The zinc finger peptides may have nucleic acid recognition sequences according to SEQ ID NO: 101. Also disclosed are methods for constructing poly-zinc finger peptides having arrays of at least 8 zinc finger domains, along with zinc finger frameworks that may be useful for selecting zinc finger peptides from libraries.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.