Devices and methods for pharmacokinetic-based cell culture system
US9732316B2 · kind B2 · utility
1Cited by
5References
12Claims
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Key dates
| Filing date | Feb 26, 2016 |
| Grant date | Aug 15, 2017 |
| Priority date | — |
| Expiry date | Feb 26, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5067
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A cell culture device comprising a microscale chamber dimensioned to maintain a cell under conditions that give rise to a value for at least one pharmacokinetic parameter in vitro that is comparable to a value for the same at least one pharmacokinetic parameter obtained with respect to the same type of cell in vivo, wherein the microscale chamber is configured for flow of culture medium, and wherein the at least one pharmacokinetic parameter is selected from tissue size ratio, tissue to blood volume ratio, drug residence time, flow rate, circulatory transit time, liquid residence time, and liquid to cell ratio.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.