Chloroplast expressing colostrum or milk polypeptides

US9732351B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Stephen Mayfield · Irvine, US
• Austin HALLGREN · Novato, US
• Beth A. Rasala · San Diego, US
• Miller Tran · San Diego, US
• Michael Mayfield · Irvine, US

Key dates

• Filing date: Apr 22, 2016
• Grant date: Aug 15, 2017
• Expiry date: Apr 22, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2002/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided are chloroplasts engineered to recombinantly express mammalian colostrum and milk polypeptides, photosynthetic organisms containing such chloroplasts, and compositions comprising such organisms and methods for producing such organisms. In certain embodiments, provided is a chloroplast comprising one or more polynucleotides encoding one or more mammalian milk or colostrum polypeptides selected from osteopontin, lactadherin, cathelicidin-1, lysozyme, lactoperoxidase, lingual antimicrobial peptide (LAP), alpha-lactalbumin, and soluble CD14.