Biochemical markers for neurodegenerative conditions
US9733260B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Jul 4, 2012 |
| Grant date | Aug 15, 2017 |
| Priority date | — |
| Expiry date | Jul 4, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/56
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein is a method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions. The method comprises cleaving a Tau protein by a secretase, such as ADAM10, to form a neo-epitope. The method comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of the antibody to peptide fragments comprising the neo-epitope in the sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
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